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Progress in Study on Complementary Origins of Myofibroblasts in Hepatic Fibrosis
Pages: 496-498
Year: Issue:  8
Journal: Chinese Journal of Gastroenterology

Keyword:  纤维化肌成纤维细胞异质性骨髓细胞单核细胞上皮细胞;
Abstract: 肝星状细胞(HSC)激活为肌成纤维细胞(MFB)并合成大量细胞外基质被认为是肝纤维化的核心机制.但新近研究表明肝纤维化中的MFB有相当多的补充来源,包括骨髓源性纤维细胞进入受损肝组织,循环中的单核细胞亚群向纤维细胞分化,以及肝细胞和胆管细胞的上皮-间质转化等.这些发现扩充了肝纤维化的发生机制,并可能提供新的诊断和治疗选择.
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