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Short-term Efficacy of Mosapride Dispersible Tablet on Postprandial Distress Syndrome
Author(s): 
Pages: 488-490
Year: Issue:  8
Journal: Chinese Journal of Gastroenterology

Keyword:  餐后不适综合征消化不良治疗莫沙必利胃排空;
Abstract: 背景:餐后不适综合征(PDS)是临床常见的功能性胃肠病,胃肠动力障碍为其重要病理生理机制之一.莫沙必利是一种胃肠促动力药,已用于胃肠动力障碍的治疗.目的:观察莫沙必利分散片治疗PDS的近期疗效.方法:60例符合罗马Ⅲ PDS诊断标准的患者随机分成M组(接受铝碳酸镁1000 mg加莫沙必利分散片5 mg tid治疗)和P组(接受铝碳酸镁1000 mg加安慰剂tid治疗),疗程均为2周.于治疗前后行患者总体PDS症状评分并检测胃排空功能.结果:两组治疗后总体PDS症状评分较治疗前均显著降低(P<0.001),其中M组评分又显著低于P组(P<0.01).M组治疗有效率为83.3%,显著高于P组(40.0%)(P<0.001).两组治疗前胃3 h排空钡条数无明显差异,均显著少于正常对照组(P<0.001).M组治疗后胃排空钡条数较治疗前和P组治疗后显著增多(P<0.001).P组治疗后与治疗前相比则无明显差异.结论:莫沙必利分散片能明显改善PDS患者的胃排空功能,对缓解餐后饱胀和早饱症状近期疗效满意.
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