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Effect of Mica on Intestinal Permeability in Experimental NSAIDs Enteropathy in Rats
Author(s): 
Pages: 478-482
Year: Issue:  8
Journal: Chinese Journal of Gastroenterology

Keyword:  消炎药非甾类小肠黏膜损伤通透性云母;
Abstract: 背景:非甾体抗炎药(NSAIDs)是消化道损伤的常见病因.已知云母对多种原因所致的胃黏膜损伤具有保护作用,但其对小肠黏膜损伤是否同样具有保护作用尚不清楚.目的:观察云母对NSAIDs肠病肠道通透性的影响,探讨云母保护小肠黏膜的可能机制.方法:24只大鼠随机分为空白组、模型组和云母组.云母组先以12 mg/ml云母混悬液1 ml/100 g灌胃一次.次日起三组分别以蒸馏水、0.78 mg/ml双氯芬酸溶液和云母混悬液+双氯芬酸溶液灌胃,剂量均为1 ml/100 g,1次/d.灌胃5 d后处死大鼠,行小肠黏膜损伤大体和组织学评分,检测24 h尿液乳果糖、甘露醇排出率和血清D-乳酸含量.结果:双氯芬酸可引起明显的小肠黏膜损伤,模型组大体,组织学评分中位数和24 h尿液乳果糖排出率显著高于空白组(P<0.05).云母组小肠黏膜损伤较模型组显著减轻,乳果糖排出率显著降低(P<0.05).三组尿液中均未检出甘露醇,血清D-乳酸含量无明显差异.结论:云母可降低小肠通透性,对NSAIDs肠病具有一定预防保护作用.
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