Author(s): ZHANG Li-ju, WANG Ling
Pages: 561-563
Year: 2009 Issue:  8
Journal: Chinese Journal of Hepatology
Keyword:  Hepatitis B virus; Disease transmission; vertical; Intrauterine infection; Telbivudine;
Abstract: Objective To investigate the efficacy of telbivudine on intrauterine hepatitis B virus (HBV) infection during the last stage of pregnancy.Methods 61 pregnant chronic hepatitis B (CHB) patients were enrolled and 31 patients were treated by telbivudine 600rag once daily,30 patients in the control group were not recieved antiviral treatment.Maternal HBV DNA level and the HBsAg positive rate in newborns were investigated.Results The levels of serum HBV DNA in patients treated with Telbivudine were significantly reduced (t=19.09,P<0.01).Compared with the control group,serum HBV DNA levels were significantly lower in telbivudine treated patients than those in the control group before parturition (t=23.64,P<0.01).The infection rate of 7-month newborns were 0 and 13.33% (4/30),in telbivudine group and control group,respectively (x2= 4.29,P<0.05).Conclusions Telbivudine treatment can block intrauterine infection in pregnant chronic hepatitis B patients.