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Diagnostic value of FDG-PET/CT in the detection of bone marrow involvement in patients with diffuse large B-cell lymphoma
Author(s): 
Pages: 832-835
Year: Issue:  12
Journal: Chinese Journal of Hematology

Keyword:  PET/CTLymphomaBone marrow involvementBiopsy;
Abstract: Objective To evaluate the diagnostic value of bone marrow(BM) involvement detected by F-18-flurodeoxyglueose-positron emission tomography/computed tomography (18F-FDG PET/CT) in patients with newly diagnosed diffuse large B-cell lymphoma(DLBCL).Methods The study population comprised 81consecutive patients with newly diagnosed DLBCL.All patients had both 18F-FDG PET/CT and standard BM biopsy at iliac crest.In 9 patients,additional direct BM biopsy at FDG-avid bone lesion was performed.Results Among all 81 eases,23 were diagnosed as BM involvement by PET/CT.Of the 23 positive eases 17 were confirmed by biopsy.However,only 11 eases were diagnosed by merely bilateral iliac crest biopsy.In patients in early stage of disease 18F-FDG PET/CT had the same results as bilateral iliae crest biopsy.Conclusion 18F-FDG PET/CT is superior to standard BM biopsy in detecting BM involvement in newly diagnosed DLBCL patients.In patients with FDG-avid bone lesions,direct PET/CT-guided bone biopsy seems to be.more accurate than standard BM biopsy.
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