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A retrospective analysis of clinical outcomes in 225 childhood acute lymphoblastic leukemia
Pages: 824-827
Year: Issue:  12
Journal: Chinese Journal of Hematology

Keyword:  LeukemialymphoblaaticacuteChildrenAntineoplastic combined chemotherapy protocols;
Abstract: Objective To retrospectively analyze the outcomes in newly diagnosed children with acute lymphoblastic leukemia (ALL).Methods Two hundred and twenty-five children with ALL (from Jan 2003 to Dec 2006) were divided into high-(HR) and standard-risk(SR) groups according to cytomorphology,immunology,cytogenetics and molecular biology (MICM) finding.SR patients were treated with conventional therapy,while HR patients with additional high-dose(HD) methotrexate (MTX) (5 g/m2) and early middose cytarabine (Ara-C) (1 g/m2,q 12h×3 d).All patients took maintenance chemotherapy of MM + VP.Respond rate(RR) and overall survival (OS) rate of patients were retrospectively analyzed.Results The probabilities of 3-year and 5-year OS were 79.0% and 72.6%,respectively.The SR patients had a remarkably higher 3-year OS (87.6%) than that of HR patients (66.1%) (P =0.002).Conclusion ①Early intensive therapy with mid-dose Ara-C and HD-MTX significantly improves the outcome of HR children with ALL.②The early intensive therapy in HR patients reduces the incidence of CNSL.③Periodic intensification and more re-induction therapies in SR patients remarkably improves the long-term survival.
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