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Active Cluster Identification Technology and Its Application in Studying the Material Base of TCM Prescriptions
Pages: 98-100
Year: Issue:  5
Journal: World Science and Technology-Modernization of Traditional Chinese Medicine

Keyword:  有效成分族辨识活血化瘀数据库搜寻;
Abstract: 本文以血管紧张素转化酶(Angiotensin Converting Enzyme,ACE)抑制剂、3-羟基-3-甲基戊二酰辅酶A还原酶(3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase,HMG-CoAR)抑制剂和血管紧张素Ⅱ(Angiotensin Ⅱ,AngⅡ)、血小板活化因子(Platelet Activating Factor,PAF)受体拮抗剂三维药效团为辨识模型,以三维数据库柔性搜索技术为辨识算法,发现了18首活血化瘀方剂及其所含20味中药可能具有的ACE、Ang Ⅱ、PAF和HMG-CoAR受体活性的物质基础.结果表明,中药有效成分族的研究将为从分子层次上揭示方剂物质基础提供方法学支撑.
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