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Effects of Qingkailing Injection (QKL) on Transforming Growth Factor-β1 (TGF-β1) Expression in Cerebral Ischemia-Reperfusion Injury in Rats
Author(s): 
Pages: 29-32,55
Year: Issue:  5
Journal: World Science and Technology-Modernization of Traditional Chinese Medicine

Keyword:  脑缺血再灌注损伤转化生长因子-β1清开灵注射液星形胶质细胞;
Abstract: 目的:探讨清开灵注射液对大鼠脑缺血再灌注损伤过程中转化生长因子-β1(TGF-B1)表达的影响.方法:雄性Wistar大鼠,随机分成正常组、模型组及清开灵注射液治疗组.反复夹闭双侧颈总动脉复制脑缺血再灌注损伤模型.利用免疫组织化学方法在缺血再灌注不同时间点分别检测脑组织中GFAP及TGF-β1的含量.结果:大鼠脑缺血再灌注损伤不同时间点脑组织中GFAP及TGF-B1的表达有不同程度增加,而清开灵注射液可不同程度地降低GFAP及TGF-β1的表达.结论:清开灵注射液可能通过抑制星形胶质细胞活性而降低TGF-β1的表达.
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