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Issue:
Expression of heat shock protein 27 in human ovarian cycle
Author(s):
MA Hong-mei
,
LIU Jia-yin
Pages:
1196
-
1197
Year:
2008
Issue:
12
Journal:
Anhui Medical and Pharmaceutical Journal
Keyword:
热休克蛋白27(HSP27)
;
多囊卵巢综合征(PCOS)
;
原始卵泡
;
卵母细胞
;
Abstract:
目的 通过研究热休克蛋白27(HSP27)在正常人卵巢周期中的不同发育阶段卵泡中的表达,探讨其在卵泡发育中的可能调控机理.方法 收集18例月经规则的生育年龄妇女不同周期阶段的卵巢组织和6例PCOS患者的卵巢组织,采用免疫组织化学方法观察HSP27蛋白在人卵巢中的定位及表达情况.结果 HSP27定位表达于人原始卵泡的卵母细胞,各期卵泡的颗粒细胞、卵泡膜细胞、黄体细胞及间质细胞均未见表达.PCOS组卵母细胞阴性表达.结论 HSP27可能和原始卵泡的卵母细胞发育与凋亡有关.
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