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Preparation and in Vivo Absorption in Rats of Puerarin Solid Dispersion
Author(s): 
Pages: 157-160
Year: Issue:  2
Journal: Heilongjiang Medicine Journal

Keyword:  葛根素固体分散体生物利用度;
Abstract: 本文采用新型的固体分散体技术,将葛根素,磷脂与PVP制成固体分散体,对其理化性质进行研究,考察固体分散体在大鼠体内的药-时曲线,计算其在大鼠体内的药动学参数,并与葛根素原料比较,研究固体分散体的相对生物利用度.结果表明以磷脂和PVP为载体制备的固体分散体(药物-磷脂-PVP,2:4:1)的表现油水分配系数最好,固体分散体相对生物利用度较纯葛根素提高了2.53倍.
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