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Research progress on midkine and follicular development
Author(s):
TANG Fei
,
ZHOU Ying
Pages:
317
-
320
Year:
2009
Issue:
3
Journal:
Journal of Reproductive Medicine
Keyword:
中期因子
;
卵泡发育
;
凋亡
;
颗粒细胞
;
Abstract:
中期因子(midkine)属于肝素结合生长因子家族中的新成员,是一种强有力的刺激细胞增殖的调节因子,表达于卵泡颗粒细胞等组织,具有抑制卵丘颗粒细胞凋亡等广泛的生物学作用.在卵泡发育过程中midkine能促进卵母细胞的发育成熟,特别是对细胞质的成熟有着重要的作用,能够提高其受精率、胚胎卵裂率和囊胚率.
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