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Research progress on midkine and follicular development
Author(s): 
Pages: 317-320
Year: Issue:  3
Journal: Journal of Reproductive Medicine

Keyword:  中期因子卵泡发育凋亡颗粒细胞;
Abstract: 中期因子(midkine)属于肝素结合生长因子家族中的新成员,是一种强有力的刺激细胞增殖的调节因子,表达于卵泡颗粒细胞等组织,具有抑制卵丘颗粒细胞凋亡等广泛的生物学作用.在卵泡发育过程中midkine能促进卵母细胞的发育成熟,特别是对细胞质的成熟有着重要的作用,能够提高其受精率、胚胎卵裂率和囊胚率.
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