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The effects of human interferon-a on proliferation and apoptosis of hepatoma cell
Author(s): 
Pages: 445-446
Year: Issue:  6
Journal: Journal of Nantong University(Medical sciences)

Keyword:  干扰素-α细胞增殖和凋亡侵袭SMMC7721细胞株;
Abstract: 目的:研究干扰素-α对人肝癌SMMC7721细胞的增殖及迁移的抑制作用,探讨其抗肿瘤作用的机制.方法:常规培养的人肝癌SMMC7721细胞,加入干扰素-α孵育24 h后,以MTT法检测干扰素-α对肿瘤细胞增殖的影响;Boyden小室法检测肝癌细胞侵袭能力的变化,通过Annexin V-FITC检测干扰素-α诱导SMMC7721细胞组的凋亡情况.结果:干扰素-α可以明显抑制体外SMMC7721细胞的增殖,诱导细胞凋亡,导致Boyden小室穿膜的肿瘤细胞数明显下降.结论:干扰素-α可以直接抑制体外肝癌细胞SMMC7721的增殖和迁移并诱导细胞凋亡.
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