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Hypoglycemic Activity of Berberine
Author(s): 
Pages: 24-26
Year: Issue:  12
Journal: Chinese Journal of Ethnomedicine and Ethnopharmacy

Keyword:  小檗碱葡萄糖性糖尿病小鼠四氧嘧啶性糖尿病大鼠降血糖;
Abstract: 目的:观察小檗碱(降糖Ⅰ号)对正常大鼠、外源性葡萄糖引起的高血糖小鼠及四氧嘧啶性糖尿病大鼠的降糖作用;方法:正常大鼠灌胃给予降糖Ⅰ号25mg?kg和50mg?kg,连续给药6天.小鼠灌胃给予葡萄糖溶液及大鼠尾静脉注射四氧嘧啶溶液制备糖尿病模型,用葡萄糖氧化酶法测定血糖含量.小鼠及大鼠灌胃给药,观察其疗效.结果:正常大鼠灌胃给药,高剂量组于给药后第4天呈现显著的降血糖作用,其作用不如优降糖稳定;一次灌胃给予降糖Ⅰ号50mg?kg和lOOmg?kg,高剂量组对葡萄糖性小鼠高血糖,均有明显的降血糖作用;按25mg?kg和50mg?kg剂量连续15天灌胃给予四氧嘧啶性糖尿病大鼠,高剂量组于给药后第6天、低剂量组第9天及降糖灵组第12天,均呈现明显的降糖作用;结论:降糖Ⅰ号具有明品的降血糖作用.
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