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Detection and Clinical Significance of the Cytokines in the Serum of Patients with Hepatic Cirrhosis
Author(s): LIU Zhen-ping, JIANG Yuan
Pages: 564-
566
Year: 2009
Issue:
5
Journal: Hebei Medicine
Keyword: 肝硬化; 细胞因子; ELISA;
Abstract: 目的:探讨肝炎后肝硬化(posthepatitic cirrhosis,PHC)患者血清中细胞因子的水平变化及其与肝功能的关系.方法:采用ELISA法测定58例PHC患者和35例健康者血清细胞因子IL-6、IL-8、TNF-a的水平.同时将肝硬化患者按Child-Pugh肝功能分级标准分成A、B、C三组.结果:肝硬化组IL-6、IL-8、TNF-a的水平明显高于对照组,差异有统计学意义(P<0.01);Child-Pugh A、B、C三级的IL-6、IL-8、TNF-a水平依次递增,且各级间差异有统计学意义(P<0.01).结论:随着IL-6、IL-8、TNF-a血清水平的升高而肝损伤程度加重,采用IL-6、IL-8、TNF-a作为临床判断肝脏损害程度的指标具有较好的临床参考价值.
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