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qian lie xian ai huan zhe xue qing se-cad de ce ding ji yu qian lie xian ai lin chuang fen ji fen qi de guan xi
Author(s): 
Pages: 53-55
Year: Issue:  32
Journal: Chinese Journal of Postgraduates of Medicine

Keyword:  前列腺肿瘤前列腺增生钙黏着糖蛋白类;
Abstract: 目的 测定前列腺癌患者血清可溶性钙黏蛋白(sE-cad)水平及sE-cad与前列腺癌临床分级、分期的关系.方法 采用ELISA法检测20例健康男性(对照组)、42例前列腺癌患者(前列腺癌组)、71例前列腺增生患者(前列腺增生组)血清sE-cad水平.结果 前列腺癌组患者血清中的sE-cad水平为(12.4860±6.1731)μg/L,明显高于前列腺增生组(6.2275±1.9518)μg/L、对照组(5.6510±1.0303)μg/L(P<0.01). 前列腺癌组不同临床分期中sE-ead水平A期(9.4732±2.5148)μg/L,B期(8.8826.±3.7830)μg/L,C期(15.9092±5.8153)μg/L,D期(19.6145±7.7869)μg,L,血滑sE-cad水平与前列腺癌的临床分期呈正相关(P<0.05).血清sE-cad水平在前列腺癌Gleason分级中高分化(10.1213±3.3904)μg/L,中分化(14.7288±9.4082)μg/L,低分化(15.4990±5.3126)μg/L,血清sE-cad水平与前列腺癌病理分级无关(P>0.05).结论 前列腺癌患者血清sE-cad水平升高,与前列腺癌的生物学特性密切相关,对前列腺癌的早期诊断以及预后具有重要临床意义.
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