Author(s): WANG Yong-lian, WANG Zhong-min, WANG Yi, YAO Wen-jian, ZHAO Bao-sheng, LI Han-chen
Pages: 609-611
Year: 2009 Issue:  8
Journal: China Medicine
Keyword:  Cadiopulmonary bypass; Heart Surgery; Heart fatty acid-binding protein;
Abstract: Objective To observe the changes of plasma heart fatty acid-binding protein (H-FABP) after open heart surgeries with different cardioplegia perfusion methods. Methods Forty congenital heart disease(CHD) patients underwent cardiac operation were randomly divided into two groups: cold crystalloid cardioplegia perfusiun group (Ⅰ,20 cases) and cold blood cardioplegia perfusion group(Ⅱ,20 cases). The plasma H-FABP concentration was detected by Enzyme-linked immunosorbent assay (ELISA) before and at different time points after CPB. Results The difference of plasma concentration of H-FABP preoperative was not significant between group Ⅰ and group Ⅱ. In both groups the plasma concentration of H-FABP during and after operation was higher than that before anesthesia. Conclusion Postoperative H-FABP concentration is significantly higher than preoperative H-FABP concentration. The level of plasma H-FABP concentration is not only related to the degree of myocardial damage but also related to the duration of aortic cross-clamping. H-FABP is a sensitive index for myocardial damage.