Respiration disorders in non-obese obstructive sleep apnea syndrome
Author(s): WANG Chun-e, YAN Gui-zhen
Pages: 176-177
Year: 2009 Issue: 3
Journal: China Medicine
Keyword: Obstructive sleep apnea syndrome; Obesity; Respiration disorders;
Abstract: Objective To investigate the features of respiration disorders in non-obese obstructive sleep apnea syndrome(OSAS). Methods All patients underwent overnight polysomnography. 36 OSAS patients with body mass index (BMI) ≤25 were enrolled into non-obese group; 36 age and sex-matched OSAS controls with BMI > 25 were enrollled into obese group. Features of respiration disorders in two groups were analyzed. Results Compared with obese OSAS, non-obese OSAS had less apnea indices (AI) and time of nocturnal oxygen saturation lower 90% (T-SaO2< 90%) and higher lowest nocturnal oxygen saturation (MinSaOz). There was no significant difference in average apnea time in two groups. For the severity of OSAS, non-obese had more mild, moderate individuals and obese had more severe individuals. Except obstructive sleep apnea, non-obese OSAS had higher ratio of mixed sleep apnea than obese OSAS (15.2% vs 6.1%, P < 0.01). Conclusion Compared with age and sex-matched obese OSAS, non-obese OSAS has less respiration disorders and higher ratio of mixed sleep apnea. Abnormal nerve accommodation in upper airway or respiratory center may play an important role in pathogenesis of non-obese OSAS.
Pages: 176-177
Year: 2009 Issue: 3
Journal: China Medicine
Keyword: Obstructive sleep apnea syndrome; Obesity; Respiration disorders;
Abstract: Objective To investigate the features of respiration disorders in non-obese obstructive sleep apnea syndrome(OSAS). Methods All patients underwent overnight polysomnography. 36 OSAS patients with body mass index (BMI) ≤25 were enrolled into non-obese group; 36 age and sex-matched OSAS controls with BMI > 25 were enrollled into obese group. Features of respiration disorders in two groups were analyzed. Results Compared with obese OSAS, non-obese OSAS had less apnea indices (AI) and time of nocturnal oxygen saturation lower 90% (T-SaO2< 90%) and higher lowest nocturnal oxygen saturation (MinSaOz). There was no significant difference in average apnea time in two groups. For the severity of OSAS, non-obese had more mild, moderate individuals and obese had more severe individuals. Except obstructive sleep apnea, non-obese OSAS had higher ratio of mixed sleep apnea than obese OSAS (15.2% vs 6.1%, P < 0.01). Conclusion Compared with age and sex-matched obese OSAS, non-obese OSAS has less respiration disorders and higher ratio of mixed sleep apnea. Abnormal nerve accommodation in upper airway or respiratory center may play an important role in pathogenesis of non-obese OSAS.
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