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dan lian kang ti biao da yan jiu jin zhan
Author(s): 
Pages: 321-322
Year: Issue:  2
Journal: The Journal of Practical Medicine

Abstract: 单链抗体(single-chain antibody fragment,scFv)由抗体重链可变区和轻链可变区通过15~20个氨基酸的短肽(linker)连接而成.在目标特定的scFv上连接放射性核素、生物毒素、药物,将极大增强对靶细胞的杀伤能力.Kanter等[1]研究发现将个体基因型scFv和细胞因子粒细胞-巨噬细胞集落刺激因子或免疫刺激肽组成融合蛋白,是一种有效治疗淋巴瘤的疫苗.Wang等[2]通过抗脱氧雪腐镰刀菌烯醇(DON)和抗单端孢霉毒素(ZEN)scFv基因融合.表达为抗DON和抗ZEN scFv,结果显示双功能抗体成功构建.并可应用于DON和ZEN检测.……
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