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ku can su dui man xing yi xing gan yan huan zhe wai zhou xue t xi bao ya qun he th1/th2 ping heng de diao jie zuo yong
Author(s): 
Pages: 274-276
Year: Issue:  2
Journal: The Journal of Practical Medicine

Keyword:  肝炎乙型慢性白细胞介素4干扰素Ⅱ型苦参素T细胞亚群;
Abstract: 目的:观察苦参素对慢性乙型肝炎患者外周血T细胞亚群和Th1/Th2平衡的调节作用.方法:选择40例轻中度慢性乙型肝炎患者(治疗组)予以口服苦参素300 mg,3次/d,疗程6个月.检测治疗前和治疗6个月后患者外周血CD4+、CD8+T细胞亚群及白介素-4(IL-4)、γ-干扰素(IFN-γ)含量的变化.选择30例正常健康体检者作为对照组.结果:与对照组比较,治疗组患者外周血CD4+明显减少,CD8+明显增加,CD4+/CD8+比值下降,经过苦参素治疗6个月后,患者外周血CD4+明显增加,CD8+明显减少,CD4+/CD8+比值增加.与对照组比较,治疗组患者外周血培养上清单个核细胞(PBMC)中IL-4水平明显上升,而IFN-γ水平明显下降,经过苦参素治疗6个月后,患者外周血培养上清PBMC中IL-4水平明显下降,而IFN-γ水平明显上升.结论:慢性乙型肝炎患者存在T细胞亚群紊乱和Th1/Th2平衡失调,苦参素既能抑制调节T细胞亚群紊乱,又能调节Th1/Th2细胞因子比例平衡,从而提高细胞免疫反应,使免疫反应由Th2型向Th1型逆转,清除细胞内病毒.
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