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a tuo fa ta ting dui ji xing guan mai zong he zheng huan zhe xue qing bai xi bao jie su -1 zhong liu huai si yin zi - de ying xiang
Pages: 270-272
Year: Issue:  2
Journal: The Journal of Practical Medicine

Keyword:  冠状动脉疾病炎症阿托伐他汀;
Abstract: 目的:检测急性冠脉综合征(acute coronary syndrome,ACS)患者经过阿托伐他汀治疗后血清白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平,探讨阿托伐他汀对ACS的治疗保护机制.方法:实验分为正常对照组(N组)、正常对照高血脂组(NH组)、ACS血脂正常组(A组)、ACS高血脂组(AH组)4组.双抗体夹心ELISA法测定各组IL-1β、TNF-α.结果:NH、A、AH组IL-1β、TNF-α浓度明显高于N组(P<0.01),A、AH组经过阿托伐他汀治疗后IL-1β、TNF-α浓度明显降低(P<0.01).结论:IL-1β、TNF-α参与了ACS的发病机制,阿托伐他汀能够抑制炎症反应防治ACS.
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