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The change of plasma soluble CD40 levels in uremic patients and its clinical significance
Author(s): 
Pages: 209-211
Year: Issue:  2
Journal: The Journal of Practical Medicine

Keyword:  尿毒症血液透析可溶性CD40CD40/CD40配体;
Abstract: 目的:检测可溶性CD40(sCD40)在尿毒症患者血浆中的水平并探讨其临床意义.方法:应用酶联免疫吸附试验(ELISA)检测20例尿毒症未透析患者(尿毒症组)、20例血液透析患者(血液透析组)和20例正常对照者(对照组)血浆标本中sCD40的浓度,分析sCD40与血肌酐(Scr)和C-反应蛋白(CRP)的相关性,并观察血液透析对sCD40的影响.结果:尿毒症组和血液透析组sCD40水平均明显高于对照组(P<0.01),血液透析组sCD40水平较尿毒症组升高(P<0.01).尿毒症组sCD40水平与Scr、CRP之间成正相关(P<0.01,P<0.05),血液透析组sCD40水平与上述指标之间无明显相关性(P>0.05).一次血液透析过程,透析前、后sCD40水平差异无显著性(P>0.05).结论:尿毒症患者血浆中sCD40水平升高,血液透析患者更明显,有可能参与尿毒症的免疫异常.
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