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Effect of c-kit mutation on the prognosis of gastrointestinal stromal tumors: a meta-analysis
Author(s): 
Pages: 857-862
Year: Issue:  11
Journal: Chinese Journal of Surgery

Keyword:  Gastrointestinal stromal tumorsPrognosisc-kit geneImatinih;
Abstract: Objective To investigate the effect of c-kit mutation on the prognosis of gastrointestinal stremal tumors. Methods A search of studies in PubMed and MedLine (from 1999 to 2008) was performed to assess the effect of c-kit mutation on the prognosis of gastrointestinal strernal tumors. The articles were retrieved with the entries of "gastrointestinal stromal tumors", "imatinib" ,"c-kit" and "mutation". A recta-analysis was performed to assess the data included. Results A total of 15 articles were collected in this analysis. No significant differences was found in incidence of mitoses ( >5/50 HPF) between the patients with wild type c-kit (wild type group) and the ones with mutated c-kit (mutation group) (P=0.710); tumor recurrence and metastasis rate after surgery was significant higher in the mutation group than that in wild type group(P=0.010) ; as for imatinib response with different c-kit mutation types, the results showed the incidence of clinical response(complete response + partial response) was significantly higher in mutation group than that in wild type group(P =0. 009) ,but the imatinib resistance rate was lower in mutation group (P=0.000) ; three studies prodded data for imatinib resistance with c-kit second mutations, the results showed the second mutations mainly focus on exon 13, 14, 17. Conclusions C-kit mutation is related closely with the incidence of recurrence and metastasis in GIST after surgery. The mutations of c-kit influences the therapeutic effects of imatinib.
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