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Preparation and Biological Activity of Poly (γ-glutamic acid)-D-galactose-esterifiable Derivative Cisplatin Complex Compound
Author(s): 
Pages: 41-46
Year: Issue:  3
Journal: China Biotechnology

Keyword:  γ-聚谷氨酸D-半乳糖顺铂抗肿瘤活性;
Abstract: 介绍了制备一种γ-聚谷氨酸-D-半乳糖酯化衍生物-顺铂复合物[poly(γ-glutamic acid)-D-galactose esterifiable derivative-cisplatin complex compound,γ-D+-DDP],并考察其抗肿瘤活性.主要通过生物发酵获得大分子γ-聚谷氨酸[poly(γ-glutamic acid),γ-PGA],利用酸降解得到可以作为药物载体的小分子γ-聚谷氨酸;利用凝胶色谱柱检验小分子γ-聚谷氨酸的分子量;利用MTT法检测该复合物的体外抗肿瘤作用.结果表明:成功获得γ-聚谷氨酸-D-半乳糖酯化衍生物-顺铂复合物,该复合物载药率达9.4%~10.2%;该复合物对人肝癌细胞BEL-7402具有显著的杀伤作用,能引起细胞凋亡(HE染色观察得到).因此,γ-聚谷氨酸-D-半乳糖酯化衍生物-顺铂复合物是一种有效的抗肿瘤药物,具有潜在的临床应用价值;生物发酵的γ-聚谷氨酸可用于药物载体,赋予药物新的特点.
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