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The Effect of Exercises and Calcium Carbonate on Bone Minerial Metabolism of Ovariectomized Rats
Author(s): 
Pages: 36-40
Year: Issue:  4
Journal: Guangdong Trace Elements Science

Keyword:  SD大鼠去卵巢碳酸钙骨矿盐含量运动;
Abstract: 用测定骨矿盐含量的方法,观察了运动和碳酸钙(CaCO3)联合应用对去卵巢大鼠骨矿盐代谢的影响.将健康4月龄雌性SD大鼠30只,用抽签法随机分成5组:正常对照组,假去卵巢组,去卵巢组,去卵巢+ CaCO3组,去卵巢+ CaCO3+运动组.去卵巢+ CaCO3组和去卵巢+ CaCO3+运动组大鼠于切除卵巢术后第2天开始给予CaCO3灌胃[元素钙20 mg/(kg·d)],持续11周;去卵巢+ CaCO3+运动组大鼠于去卵巢术后第7天开始运动训练,每周5 d,每天连续匀速跑45 min,16 m/min,跑道倾角0°,持续10周.结果表明,去卵巢组大鼠骨干质量、骨干质量/体质量、骨灰质量、骨灰质量/体质量、骨灰质量/骨干质量(%)均明显低于假去卵巢组;去卵巢+ CaCO3组大鼠骨干质量、骨干质量/体质量、骨灰质量、骨灰质量/体质量、骨灰质量/骨干质量(%)等指标虽然较去卵巢组增加,但骨灰质量、骨灰质量/体质量、骨灰质量/骨干质量(%)等指标仍显著低于假去卵巢组;运动和CaCO3联合应用后,上述各指标均显著回升,并且基本恢复到对照组水平.提示运动可加强CaCO3抗去卵巢大鼠骨矿盐丢失的作用.
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