Author(s): SHEN Jin-chun, GUO Hai-feng, YANG Jian-jun
Pages: 383-386
Year: 2009 Issue:  5
Journal: The Journal of Clinical Anesthesiology
Keyword:  Flurbiprofen axetil; Morphine; Postoperative analgesia;
Abstract: Objective To observe the effects of postoperative analgesia with flurbiprofen axetil and morphine on morphine requirements and intestinal function recovery in patients after gastric cancer surgeries. Methods Forty patients undergoing elective gastric cancer surgery under general anesthesia were randomly allocated into flurbiprofen axetil group(A) and morphine group(B) with 20 cases each. The patients in group A and B received intravenous flurbiprofen axetil and intralipid 0. 5 h before surgery, respectivel,which were repeaded at 6 h later. All patients received patient-controlled intravenous analgesia (PCIA) postoperatively. The scores of VAS and BCS, and the requirements of morphine were recorded at 12, 24, 36, and 48 h after operation. The time of first flatus after operation was recorded. Results The scores of VAS and BCS were not significantly different between the two groups at all time points. The requirements of morphine in group A was significantly lower than that in groupB[(16.99±3.51)mg vs. (25.09±4. 63) mg](P<0.01). The time of first flatus was earlier in group A than that in group B(P<0.05). Conclusion Perioperative administration of flurbiprofen axetil may reduce morphine requirements during PCIA and facilitate intestinal function recovery in patients after gastric cancer surgery.