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Apoptosis of grass carp (Ctenopharngodon idellus) iymphocytes induced by the combination of microcystins and disinfection by-products in drinking water
Author(s): 
Pages: 228-232
Year: Issue:  1
Journal: Chinese Journal of Applied Ecology

Keyword:  微囊藻毒素细胞凋亡消毒副产物复合污染细胞毒性;
Abstract: 针对饮用水中消毒副产物与微囊藻毒素的低剂量复合污染问题,采用离体细胞培养诱导方法,以草鱼淋巴细胞为暴露受体,研究了MCLR、MCRR两种微囊藻毒素和CHCIBr2、CHCU2Br两种消毒副产物的单独与联合毒效应.结果表明:4种污染物在试验浓度下暴露2 h即能使草鱼淋巴细胞发生凋亡,且呈显著的剂量一效应关系;1 nmol·L-1MCLR、MCRR分别和1~100 nmol·L-1的CHCI2Br、CHClBr2的联合作用均表现为相加作用,并且均呈显著的剂量-效应关系.草鱼淋巴细胞凋亡率可作为一种有效的指标来评价微囊藻毒素及消毒副产物复合污染引起的细胞毒性.
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