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Salidroside inhibits H2O2-induced apoptosis in PC12 cells by preventing cytochrome?c release and inactivating of caspase cascade
Pages: 796-802
Year: Issue:  9
Journal: Acta Biochimica et Biophysica Sinica

Keyword:  salidroside; hydrogen peroxide; apoptosis; PC12 cells;
Abstract: We used a rat pheochromocytoma (PC12) cell line to study the effects of salidroside on hydrogen peroxide (H2O2)-induced?apoptosis. In PC12 cells, H2O2-induced apoptosis was accompanied?by the down-regulation of Bcl-2, the up-regulation?of Bax, the release of mitochondrial cytochrome c to cytosol, and the activation of caspase-3, -8 and -9. However, salidroside suppressed the down-regulation of Bcl-2, the up-regulation of Bax and the release of mitochondrial cytochrome c to cytosol. Moreover, salidroside attenuated caspase-3, -8 and -9 activation, and eventually protected cells against H2O2-induced apoptosis. Taken together, these results suggest?that treatment?of PC12 cells with salidroside can block H2O2-induced apop璽osis by regulating Bcl-2 family members and by suppressing?cytochrome c release and caspase cascade activation.
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