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Synthesis of Ciprofloxacin-Bonded Polymer Prodrug
Author(s): 
Pages: 54-57
Year: Issue:  5
Journal: JOURNAL OF PUTIAN UNIVERSITY

Keyword:  高分子前药物环丙沙星聚氨酯;
Abstract: 以抗茵药物-盐酸环丙沙星(CIPRO)代替传统的聚氨酯扩链剂,采用六亚甲基二异氰酸酯(HDI)、聚己内酯(PCL)为原料,通过典型的两步聚氨酯缩合反应,成功地将药物耦合到聚氨酯的骨架结构上,合成了环丙沙星-聚氨酯高分子前药物.研究了不同加料顺序对药物含量和平均分子量的影响.结果表明,合成的高分子前药物具有较高的药物含量、平均分子量和较窄的分散性.
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