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Treatment of Helicobacter pylori in surgical practice: A randomised trial of triple versus quadruple therapy in a rural district general hospital
Author(s): 
Pages: 3855-3860
Year: Issue:  24
Journal: WORLD JOURNAL OF GASTROENTEROLOGY

Keyword:  Helicobacter pyloriTriple therapyQuadruple therapySide effectsTreatment complianceEradication rate;
Abstract: AIM: To compare a lansoprazole-based triple versus quadruple therapy for Helicobacter pylori (H pylori)eradication with emphasis on side effect profile,patient compliance and eradication rate at a rural district general hospital in Wales,United Kingdom.METHODS= One hundred one patients with H pylori infection were included in the study.Patients were randomised to receive triple therapy comprising of lansoprazole 30 mg,amoxycillin 1 g,clarithromycin 500 mg,all b.d.(LAC),or quadruple therapy comprising of lansoprazole 30 mg b.d.,metronidazole 500 mg t.d.s.,bismuth subcitrate 240 mg b.d.,and tetracycline chloride 500 mg q.d.s.(LMBT).Cure was defined as a negative 13C urea breath test 2 mo after treatment.RESULTS: Seven patients were withdrawn after randomisation.Fifty patients were assigned to LAC group and 44 to LMBT group.The intention-to-treat cure rates were 92% and 91%,whereas the perprotocol cure rates were 92% and 97%,respectively.Side effects were common,with 56% experiencing moderate to severe symptoms in the LAC group and 59% in the LHBT group.Symptoms of vomiting,diarrhoea and black stools were significantly more common in the LMBT group.Patient compliance was 100% for triple therapy and 86% for quadruple therapy (P<0.01).One-third of patients in both groups were still taking acid-reducing medications at six-month follow-up.CONCLUSION: One-week triple and quadruple therapies have similar intention-to-treat eradication rates.Certain side effects are more common with quadruple therapy,which can compromise patient compliance.Patient education or modifications to the regimen are alternative options to improve compliance of the quadruple regimen.
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