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Association between gene polymorphism of interleukin-4 receptor Q576R and allergic rhinitis
Author(s): 
Pages: 261-263,269
Year: Issue:  4
Journal: ANATOMY RESEARCH

Keyword:  变应性鼻炎白介素4受体基凶Q576R基因多态性;
Abstract: 目的 对变应性鼻炎患者行白介素4受体基因Q576R分型,探讨白介素4受体基因Q576R基因与变应性鼻炎遗传易感性的相关性.方法 用PCR-RFLP法为69名无亲缘关系的变应性鼻炎患者和91名无血缘关系的健康汉族人行白介素4受体基凶Q576R分型.结果 AR组中TIgE含量明显高于对照组.(P<0.001),Q576R各基凶型之间TIgE无显著性差异,在AR组中QR基因型频率高于对照组(P=0.007),QQ基因型频率低于对照组(P=0.02).AR组与对照组之间等位基因频率存在显著性差异(P=0.005),AR组的R等位基因频率高于对照组(OR=2.18).结论 Q576R基因多态性与AR存在相关性,R等位基凶可能是AR的易感基因.
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