Progress in the construction of tissue-engineered adipose tissue
Author(s): Li Zhi-gang, Li Wei-ru
Pages: 4727-4730
Year: 2008 Issue: 24
Journal: JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH
Keyword: 脂肪组织; 组织工程; 综述文献;
Abstract: 学术背景:软组织缺损的修复是整形外科最重要的难题,目前的各种方案都存在一定缺陷,脂肪组织工程技术为解决上述难题提供了一种新的途径.目的:分析脂肪组织工程的研究现状及目前方案的缺陷,对其将来可能的临床应用进行相应展望.检索策略:应用计算机检索 Medline数据库1991-01/2007-07相关组织工程化脂肪组织构建的文献,检索词"fat,Tissueengineering",限定文章语言种类为English.同时计算机检索中国期刊全文数据库1991-01/2007-07的相关文献,检索词"脂肪,组织工程",限定文章语言种类为中文.共榆索到英文文献241篇,中文文献101篇.阅读标题和摘要进行初筛,纳入标准:与组织工程化脂肪组织构建相关的文献.排除重复研究276篇.文献评价:保留66篇中英文文献进一步分析,最终纳入符合标准的文献30篇.资料综合:构建组织工程化脂肪的要素包括细胞类型、支架和血液供应及微环境.脂肪组织的缺损和不足是常年困惑整形外科医生的问题.通常采用的自体游离组织移植中,移植物的吸收限制了其进一步应用.组织工程技术的发展为解决上述问题提供了可能的途径.目前,鉴于重建美容外科的巨大需求,脂肪组织的组织工程构建已经逐渐成为了一个研究的焦点.结论:组织工程化的脂肪组织真正应用丁临床,移植物必须能长年保持正常的形态和功能,组织工程化的脂肪将能为临床彻底解决软组织缺损等难题展示美好的前景.
Pages: 4727-4730
Year: 2008 Issue: 24
Journal: JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH
Keyword: 脂肪组织; 组织工程; 综述文献;
Abstract: 学术背景:软组织缺损的修复是整形外科最重要的难题,目前的各种方案都存在一定缺陷,脂肪组织工程技术为解决上述难题提供了一种新的途径.目的:分析脂肪组织工程的研究现状及目前方案的缺陷,对其将来可能的临床应用进行相应展望.检索策略:应用计算机检索 Medline数据库1991-01/2007-07相关组织工程化脂肪组织构建的文献,检索词"fat,Tissueengineering",限定文章语言种类为English.同时计算机检索中国期刊全文数据库1991-01/2007-07的相关文献,检索词"脂肪,组织工程",限定文章语言种类为中文.共榆索到英文文献241篇,中文文献101篇.阅读标题和摘要进行初筛,纳入标准:与组织工程化脂肪组织构建相关的文献.排除重复研究276篇.文献评价:保留66篇中英文文献进一步分析,最终纳入符合标准的文献30篇.资料综合:构建组织工程化脂肪的要素包括细胞类型、支架和血液供应及微环境.脂肪组织的缺损和不足是常年困惑整形外科医生的问题.通常采用的自体游离组织移植中,移植物的吸收限制了其进一步应用.组织工程技术的发展为解决上述问题提供了可能的途径.目前,鉴于重建美容外科的巨大需求,脂肪组织的组织工程构建已经逐渐成为了一个研究的焦点.结论:组织工程化的脂肪组织真正应用丁临床,移植物必须能长年保持正常的形态和功能,组织工程化的脂肪将能为临床彻底解决软组织缺损等难题展示美好的前景.
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