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Effect of microinjection of oxytocin into the paraventricular nucleus on gastrin expression in gastric mucosa following gastric ischemia/reperfusion in rats
Author(s): 
Pages: 424-428
Year: Issue:  7
Journal: ACTA ACADEMIAE MEDICINAE XUZHOU

Keyword:  胃缺血/再灌注室旁核催产素胃泌素;
Abstract: 目的 研究室旁核(paraventricular nucleus,PVN)内微量注射催产素(oxytocin,OT)对大鼠胃缺血/再灌注(gastric ischemia/reperfusion,GI/R)后胃黏膜细胞胃泌素表达的影响.方法 采用夹闭大鼠腹腔动脉30 min,去除动脉夹再灌注1 h的GI/R损伤模型,于单侧PVN微量注射OT.肉眼计数胃黏膜损伤指数,并运用免疫组化实验技术观察了PVN微量注射OT对胃黏膜细胞胃泌素蛋白表达的影响.结果 PVN微量注射OT可明显减轻GI/R损伤;PVN内微量注射OT能明显减少GI/R后胃黏膜细胞胃泌素的表达,侧脑室给予OT特异性拮掂剂atosiban后阻断OT对大鼠GI/R损伤的保护作用并使胃泌素的表达增加.结论 PVN微量注射OT后对GI/R损伤具有显著的保护作用,这种保护作用在脑内是由OT受体介导的,在胃黏膜局部与抑制胃黏膜细胞胃泌素的表达有关.
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