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Association between estrogen receptor alpha gene polymorphism and Alzheimer disease
Author(s): 
Pages: 20-23
Year: Issue:  28
Journal: CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE

Keyword:  雌激素受体α基因多态性Alzheimer病性别;
Abstract: 目的 探讨中国汉族人群中雌激素受体(ER)α基因多态性与Alzheimer病(AD)的相关性及性别因素对其关联性的影响.方法 采用聚合酶链反应限制片段长度多态性方法,检测63例AD(AD组)及70例健康对照者(对照组)的ER α Pvu Ⅱ、Xba Ⅰ酶切基因多态性.结果 AD组ER α等位基因x的频率、Pp、xx、Ppxx型较对照组明显增加,而PP、XX、PPXX型明显减少,P<0.05;Xba Ⅰ酶切基因多态性xx、Ppxx型与AD发病存在明显正相关关系(OR为2.34,95% CI 1.47~4.09;OR为1.79,95%CI 1.26~3.12,P均<0.05).Pp型与AD发病无明显相关关系(OR为1.58,95%CI 1.15~2.12,P>0.05).性别因素对ERα基因多态性与AD的相关性无明显影响.结论 ER α xx或Ppxx型是AD发病的危险因素,ER α Xba Ⅰ酶切基因多态性xx型可能与中国汉族AD的发病有相关性,性别因素对其相关性无影响.
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