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The relationship between the level of thrombomodulin, anticoagulation and fibrinolytic index in liver cirrhosis patients and Child-Pugh grading
Author(s): 
Pages: 27-29
Year: Issue:  28
Journal: CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE

Keyword:  肝硬化血栓调节蛋白Child-Pugh分级;
Abstract: 目的 探讨肝硬化患者血栓调节蛋白(TM)、抗凝及纤溶系统指标的变化及其与Child-Pugh分级的关系.方法 肝硬化患者77例,按Child-Pugh分级进行分组:A级组12例,B级组32例,C级组33例;对照组20例.均检测TM、抗凝血酶-Ⅲ(AT-Ⅲ)、蛋白-C(PC)、蛋白-S(PS)、D-二聚体、组织纤溶酶原激活物(t-PA)和纤溶酶原激活物抑制剂-1(PAI-1).结果 在对照组、A级组、B级组、C级组中,TM随病情加重而升高,分别为(4.24±0.81)μg/L、(4.36±2.56)μg/L、(6.66±3.30)μg/L、(6.79±3.69)μg/L;AT-Ⅲ随病情加重而逐渐降低,分别为(102.35±8.12)%、(105.46±8.71)%、(102.09±8.39)%、(94.32±9.85)%;PC和PS随病情加重而有逐渐减低的趋势;D-二聚体随病情加重而逐渐增高,分别为(0.27±0.13)mg/L、(0.42±0.26)mg/L、(0.79±0.35)mg/L、(0.93±0.43)mg/L;t-PA和PAI-1随肝功能恶化而变化的现象不明显.结论 肝硬化患者的TM、抗凝和纤溶系统指标存在明显的异常且和Child-Pugh分级相关.检测以上指标有助于对肝功能损害程度及预后的判断.
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