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Correlation between adiponectin levels and severity of coronary artery atherosclerosis in patients with metabolic disorder
Author(s): 
Pages: 30-32
Year: Issue:  28
Journal: CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE

Keyword:  代谢综合征脂联素动脉粥样硬化Gensini评分;
Abstract: 目的 探讨代谢紊乱患者血清脂联素水平及其与冠状动脉病变程度的关系.方法 100例患者分为代谢综合征组和对照组,分别行冠状动脉造影检查及血清脂联素水平的检测,对比各组血清脂联素水平和冠状动脉病变程度的差异.结果 (1)代谢综合征组空腹血糖(FPG)、三酰甘油(TG)、稳态模型评估法计算的胰岛素抵抗指数(HOMA-IRI)、体重指数、腰围、收缩压、舒张压和Gensini评分均高于对照组,血清脂联素和高密度脂蛋白-胆固醇(HDL-C)水平低于对照组(P<0.01).(2)随着代谢紊乱数目的 增加,血清脂联素水平逐渐下降,Gensini评分逐渐升高(P<0.05或<0.01).1项及以下代谢紊乱者与2项及以上代谢紊乱者之间的冠心病患者比例比较,差异有统计学意义(P<0.01).(3)脂联素与HDL-C呈正相关,与Gensini评分、TG及代谢紊乱数目呈负相关.结论 代谢紊乱患者随着代谢紊乱数目的 增加,血清脂联素水平降低,冠状动脉粥样硬化程度加重.
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