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Concentrations of serum TNF-α,IL-1β,plasma Ang Ⅱ and its clinical significance in the patients with chronic heart failure
Author(s): 
Pages: 42-43,46
Year: Issue:  28
Journal: CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE

Keyword:  心力衰竭细胞因子;
Abstract: 目的 探讨慢性心力衰竭患者血清肿瘤坏死因子(TNF)-α、白细胞介素(IL)-1 β、血浆血管紧张素Ⅱ(Ang Ⅱ)含量及其临床意义.方法 62例慢性心力衰竭患者(慢性心力衰竭组),按NYHA分级又分为3组:NYHA分级Ⅱ级组20例,NYHA分级Ⅲ级组20例,NYHA分级Ⅳ级组22例;另选择15例健康人作为对照组.测定血清TNF-α、IL-1 β及血浆Ang Ⅱ含量.结果 慢性心力衰竭组血清TNF-α、IL-1 β及血浆Ang Ⅱ含量显著高于对照组.慢性心力衰竭患者NYHA分级各组间血浆Ang Ⅱ含量比较,差异也有统计学意义.相关分析显示血浆Ang Ⅱ含量与血清TNF-α、IL-1 β含量呈显著正相关.结论 慢性心力衰竭患者血清TNF-α、IL-1 β及血浆Ang Ⅱ共同参与慢性心力衰竭的发病机制,它们之间可能还有相互作用.
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