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jia an die zuo liu dan huang zuo zuo liu suan zuo lv zuo lian he zhi liao lei feng shi guan jie yan liao xiao ji an quan xing yan jiu
Author(s): 
Pages: 52-53,55
Year: Issue:  28
Journal: CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE

Keyword:  类风湿关节炎甲氨蝶呤柳氮磺吡啶硫酸羟氯喹;
Abstract: 目的 比较甲氨蝶呤、柳氮磺吡啶、硫酸羟氯喹三联治疗与甲氨蝶呤、柳氮磺吡啶二联治疗类风湿关节炎的疗效及其安全性.方法 将48例类风湿关节炎患者随机分为两组:三联治疗组23例,接受甲氨蝶呤(10.0 mg/周)、柳氮磺吡啶(1.0 g每日2次)、硫酸羟氯喹(0.1 g每日2次)治疗;二联治疗组25例,接受甲氨蝶呤(10.0 mg/周)、柳氮磺吡啶(1.0 g每日2次)治疗.观察治疗1年后两组患者的临床改善情况及药物不良反应.结果 按美国风湿病协会(ACR)类风湿关节炎缓解标准,治疗1年后三联治疗组ACR是20%改善率为70%,而二联治疗组仅为39%(P=0.04);两组ACR50%改善率分别为55%和22%,差异有统计学意义(P=0.02).两组的不良反应发生情况比较,差异无统计学意义(P>0.05).结论 甲氨蝶呤、柳氮磺吡啶、硫酸羟氯喹三联治疗类风湿关节炎的疗效优于甲氨蝶呤、柳氮磺吡啶二联治疗,且耐受性好.
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