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chi xu qi dao zheng ya tong qi dui zu sai xing shui mian hu xi zan ting zong he zheng huan zhe xue shuan qian zhuang tai de ying xiang
Author(s): 
Pages: 58-59
Year: Issue:  28
Journal: CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE

Keyword:  阻塞性睡眠呼吸暂停综合征持续气道正压通气;
Abstract: 目的 观察持续气道正压(CPAP)通气对阻塞性睡眠呼吸暂停综合征(OSAS)患者血栓前状态的影响.方法 将30例中或重度OSAS患者随机分为试验组和对照组,每组各15例,另选15例健康者作为正常组.对照组给予一般治疗,试验组给予CPAP通气和一般治疗,连续治疗6个月.对照组和试验组分别于治疗前和治疗6个月时测定血浆α-颗粒膜蛋白(GMP-140)、血管性假血友病因子(vWF)、抗凝血酶Ⅲ(AT-Ⅲ)、D-二聚体(D-D),比较两组治疗前后及与正常组上述各项指标的差异.结果 试验组和对照组患者治疗前GMP-140、vWF、D-D均显著高于正常组(P<0.05);试验组治疗后上述指标较治疗前明显下降(P<0.01).试验组和对照组患者血浆AT-Ⅲ显著低于正常组(P<0.05);试验组治疗后较治疗前明显升高(P<0.01).而对照组治疗前后上述指标比较,差异均无统计学意义.结论 中或重度OSAS患者存在血栓前状态的血液学异常,CPAP通气对0SAS患者的血栓前状态有显著治疗作用.
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