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Micro-pump infusion of ketamine etomidate for tangential excision and skin grafting for burn Clinical Study
Author(s): 
Pages: 17-19
Year: Issue:  5
Journal: WORLD HEALTH DIGEST·MEDICAL MONTHLY

Keyword:  依托咪酯氯胺酮烧伤削痂植皮术;
Abstract: 目的观察和研究微泵输注依托咪酯复合氯胺酮静脉全麻用于烧伤削痂植皮术患者的麻醉效果以及安全性.方法:择期中、重度烧伤病人削痴植皮术42例,随机分为依托味酯复合氯胺酮组(E+K组,21例),氯胺酮组(K组,21例).两组病人分别给予味唑安定0.15mg.kg-1,依托咪酯0.3mg.kg-1,氯胺酮1.5mg.kg-1麻醉诱导后,置喉罩保留自主呼吸.麻醉维持:E+K组双道微量注射泵分别输注依托咪酯0.3mg.kg-1,h-1、氯胺酮2mg.kg-1.h-1;K组微泵输注氯胺酮4mg.kg-1.h-1;观察并记录病人注药后5min,喉罩置入5min,削痂、取皮、植皮、停药后10min患者的收缩压(SBP)、舒张压(DBP)、心率(HR)、呼吸(RR)、血氧饱和度(SPO2)的变化.同时观察氯胺酮用药量、麻醉起效时间、停药恢复过程呼之睁眼、清醒时间.结果:氯胺酮用药量K组高于E+K组42.86%;E+K组:SBP、DBP、HR变化无显著差异(P>0.05);K组:SBP、DBP、HR有显著差异(P<0.01);停药后睁眼、清醒时问E+K组明显快于K组.结论:依托咪酯复合氯胺酮用于烧伤削痴植皮术麻醉安全有效、调控方便迅速、可控性强、对循环、呼吸影响轻微,镇静镇痛效果明显.
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