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Role of pyrrolidine dithiocarbamate in intestinal ischemia / reperfusion injury
Author(s): 
Pages: 1497-1499
Year: Issue:  9
Journal: THE JOURNAL OF PRACTICAL MEDICINE

Keyword:  再灌注损伤四氢化吡咯二硫代氨基甲酸酯小肠;
Abstract: 目的:观察四氢化吡咯二硫代氨基甲酸酯(PTDC)对大鼠肠缺血再灌注后肠组织损伤的影响.方法:36只SD大鼠随机分为3组,每组12只.(1)缺血再灌注组(I/R组),暴露腹腔后夹闭肠系膜上动脉(SMA)60 min,开放灌注120 min;(2)PTDC组(P组),在肠缺血前5 min静脉给予PTDC 100 mg/kg;(3)假手术组(S组).仅暴露SMA,不行肠缺血再灌注及PTDC注射.所有动物于再灌注120 min时处死,行肠组织苏木精-伊红染色观察肠损伤程度并评分;检测肠组织中丙二醛(MDA)含量及髓过氧化物酶(MPO)、谷胱甘肽过氧化物酶(GSH-PX)活性.结果:与S组相比,I/R组、P组GSH-PX活性明显降低(P<0.01,P<0.05),MDA含量、MPO活性及小肠损伤评分明显升高(P<0.01,P<0.05).与I/R组相比,P组小肠损伤评分、MDA含量及MPO活性明显降低,GSH-PX活性明显升高(均P<0.05).结论:PDTC对大鼠肠缺血再灌注后的肠道有保护作用,该保护作用与抑制中性粒细胞浸润、减少脂质氧化程度及氧自由基有关.
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