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Association of expressions of P-STAT3 and cyclinD1 with the pathological features in cervical carcinoma
Author(s): 
Pages: 1533-1535
Year: Issue:  9
Journal: THE JOURNAL OF PRACTICAL MEDICINE

Keyword:  宫颈肿瘤免疫组织化学P-STAT3cyclinD1;
Abstract: 目的:探讨磷酸化转录信号转导子及激活子3(P-STAT3)和细胞周期素D1(cyclinD1)的表达与宫颈癌临床病理生物学行为的关系以及它们之间的相关性.方法:应用免疫组化方法对40例宫颈癌组织进行P-STAT3和cyclinD1蛋白检测.结果:P-STAT3和cyclinD1的表达与宫颈癌临床分期、组织分化、淋巴结转移及浸润深度有关,P-STAT3和cyclinD1在宫颈癌组织中表达呈正相关.其共同强表达者发生淋巴结转移与深度浸润的几率明显高于其中之一强表达者(P<0.05).结论:P-STAT3和cyclinD1的过表达促进宫颈癌的浸润转移.两者具有正协同作用.联合检测P-STAT3和cyclinD1蛋白可作为预测宫颈癌的浸润转移及评价患者预后的生物学指标.
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