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wei chuang zhi guan xiong qiang nei guan zhu shun bo he zi shan chun zhi liao fei ai e xing xiong qiang ji ye
Author(s): 
Pages: 1541-1542
Year: Issue:  9
Journal: THE JOURNAL OF PRACTICAL MEDICINE

Keyword:  胸腔积液恶性肺肿瘤顺铂紫杉醇;
Abstract: 目的:评价微创置管胸腔闭式引流结合胸腔内局部灌注顺铂和紫杉醇联合化疗治疗肺癌恶性胸腔积液的临床价值.方法:45例肺癌恶性胸腔积液患者被单盲随机分为联合化疗组和对照组,两组均应用微创置管胸腔闭式引流结合局部化疗,联合化疗组所用药物为顺铂+紫杉醇,对照组所用药物为单药顺铂,观察胸腔积液控制情况及患者生存质量.结果:联合化疗组胸腔积液控制有效率为87.0%,完全缓解率70.0%;对照组有效率为50.0%.完全缓解率为36.4%,差异均有统计学意义(P<0.05).联合化疗组生存质量好转优于对照组.结论:微创置管胸腔闭式引流结合局部灌注顺铂和紫杉醇联合化疗在有效控制肺癌恶性胸腔积液、提高患者生存质量方面明显优于单药化疗,值得推广应用.
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