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yi bing fen dui lao nian kai xiong shou shu huan zhe wei shu qi xin ji mei ji xin ji ji gai dan bai t de ying xiang
Author(s): 
Pages: 1628-1629
Year: Issue:  9
Journal: THE JOURNAL OF PRACTICAL MEDICINE

Keyword:  二异丙酚外科手术心肌酶谱肌钙蛋白老年人;
Abstract: 目的:比较不同剂量异丙酚对老年开胸手术患者围术期心肌酶及心肌肌钙蛋白T(cTnT)的影响.方法:选择择期老年开胸手术患者40例,ASA Ⅰ~Ⅱ级,年龄60~80岁,麻醉诱导后持续输注异丙酚A组2 mg/(kg·h),B组4 mg/(kg·h).于麻醉前,术毕,术后6、24、48 h采血检查血清肌酸激酶(CK)、肌酸激酶同工酶(CKMB)、天冬氨酸氨基转移酶(AST)、乳酸脱氢酶(LDH)及cTnT的浓度.结果:两组镇痛效果差异无显著性.A组CK、AST、LDH在术毕及术后均明显高于麻醉前(P<0.05),cTnT在术后均显著高于麻醉前(P<0.1).B组各指标变化与麻醉前差异均无显著性(P>0.05);B组的CK、AST在术毕及术后6 h显著低于A组(P<0.05),LDH在术后6 h显著低于A组(P<0.05),而cTnT在术后6、24及48 h均显著低于A组(P<0.05).结论:异丙酚4 mg/(kg·h)用于老年开胸手术患者更能减少老年患者围术期心肌的受损.
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