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acpi xiao shu wei he shi yan
Author(s): 
Pages: 4,8
Year: Issue:  3
Journal: HEILONGJIANG MEDICAL JOURNAL

Keyword:  ACPI微核;
Abstract: ACPI是本所制剂室研制的一种新药,为使该药能安全应用于临床,我们做了ACPI的小鼠微核试验. ACPI设2500、1250、625mg/kg(相当于1/2、1/4、1/8LD50)三个剂量组,和一个生理盐水溶剂对照组及环磷酰胺(50mg/kg)阳性对照组.给药途径鼠尾静脉0.2ml/10g.高剂量组于12、24、36、48、72h处死检查,其它各组均于给药后24h处死检查.实验结果表明ACPI对染色体无损伤作用.
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