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Prevalence of extended-spectrum beta-lactamase producing Escherichia coil in pediatric patients in China
Author(s): 
Pages: 1372-1375
Year: Issue:  20
Journal: NATIONAL MEDICAL JOURNAL OF CHINA

Keyword:  Drug resistancemicrobialMicrobial sensitivity testsDrug resistancemultipleAnti-bacterial agents;
Abstract: Objective To study the drug resistance profiles of extended spectrum beta lactamase(ESBL)producing Escherichia coli(E coli)and provide guidance for pediatric clinical prescription. Methods 5127 strains of ESBL producing E. coli were isolated from 5 children's hospitals in Beijing, Shanghai, Chongqing, and Guangzhou. The minimum inhibitory concentration(MIC)values of 349 strains to 9 antibiotics most in use in pediatrics were measured with agar dilution method. Results The prevalent rate of ESBL producing of E. coli was 46.7%. The resistant rates to ampicllin/clavulanie acid, cefotaxime, ceflazidime, and cefepime were 23.1%, 67.2%, 24.5%, and 48.4%respectively, and the intermediate rates were 38.5%, 26.4%, 5.7%, and 19.1% respectively. The resistant rate to amikacin was 5.4%. All the strains were susceptive to imipenem. The MIC90 values of ampicillin, cefotaxime, cefepime, ciprofloxacin, and gentamicin were 256 mg/L or higher. There were differences in the resistance profile to ampicllin/clavulanic acid, cefepime, ciprofloxacin, and gentamicin among different regions. Conclusion ESBL is extensively prevalent among the E. coli strains isolated from the pediatric clinic that are resistant to most antimicrobial agents except imipenem and amikacin. Regional difference exists in drug resistance to some agents exist.
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