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ercc2/xpd ji yin duo tai xing yu fei ai feng xian de yan jiu jin zhan
Author(s): 
Pages: 143-146
Year: Issue:  2
Journal: ZHEJIANG PRACTICAL MEDICINE

Keyword:  ERCC2/XPD遗传学肺肿瘤多态性着色性干皮病;
Abstract: 切除修复交叉互补基因(ERCC2)/着色性干皮病基因(XPD)是一种重要的 DNA 损伤修复基因,参与 DNA核苷酸切除修复.XPD 基因几个核苷酸序列中存在多态性,其中 312Asp/Asn和 751Lys/Gln 多态性比较常见.吸烟可引起人体细胞 DNA 损伤,90% 以上的肺癌是由于主动吸烟或被动吸"二手"烟所致.本篇综述主要阐述XPD 基因多态性及吸烟因素交互作用与肺癌风险的关系.
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