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Issue:
Expression and Clinical Significance of Human Beta-defensin-2 in Lung Carcinoma
Author(s):
XIONG Sheng-dao
,
DAI Bai-zhang
,
XIONG Wei-ning
,
LAN Fen
Pages:
110
-
112
Year:
2008
Issue:
2
Journal:
CANCER RESEARCH ON PREVENTION AND TREATMENT
Keyword:
β-防御素-2
;
肺癌
;
蛋白质印迹
;
免疫组织化学
;
Abstract:
目的 探讨人β-防御素-2(hBD-2)在肺癌组织中的表达及其临床意义.方法 收集32例不同类型肺癌的标本,每份标本取癌组织及癌旁正常组织.采用免疫组化及Western blot检测其hBD-2的表达,并作半定量分析.结果 hBD-2在癌组织中的表达高于正常组织,其表达在不同的临床分期之间存在显著性差异,而在不同病理类型的癌症组织中的表达差异无统计学意义.同样,免疫组化显示hBD-2在肺癌组织表达较正常组织高.结论 人β-防御素-2可能参与肺癌的发病机制,其表达水平可能与肺癌病情进展有关.
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