Changes of plasma cytokines in patients with severe hepatitis treated with a probiotic preparation
Author(s): LU Ming-qin, ZHENG Yu, CHEN Yong-ping, LI Ji, YE Hao-hao
Pages: 283-285
Year: 2008 Issue: 4
Journal: CHINESE JOURNAL OF HEPATOLOGY
Keyword: Liver failure; Microbial antagonism; TUmor necrosis factor-alpha; Interleukin;
Abstract: Objective To study the changes of plasma cytokines in patients with severe hepatitis treated with a probiotic preparation.Methods One hundred twelve patients with severe hepatitis treated with a basic regimen were randomly divided into a probiotic preparation treatment group and a control group.Their plasma cytokines such as tumor necrosis factor alpha,interleukin-2,interleukin-6,interleukin-10,were determined by conventional techniques.Results Clinical symptoms of 84.5%of the treatment group were obviously improved.The treatment effectiveness in this group was better than that in the control group (X2=8.888,P＜0.01).It showed that liver functions were significantly improved compared to those of the control group(P＜0.01).After the probiotic preparation therapy,there were significant decreases in the concentrations of TNFα and IL-6.TNFαand IL-6 in the treatment group and in the control group were(109.4±14.7)pg/ml vs(128.7±18.8)pg/ml and(84.3±20.1)pg/ml vs(109.1±18.7)pg/ml respectively(P＜0.01).However,theconcentrations of IL-10andIL-2inthetreatmentgroupincreasedobviously:IL-2 was(59.8±12.2)pg/ml vs(47.1±6.7)pg/ml and IL-10 was(30.6±6.6)pg/ml vs(22.5±6.1)pg/ml (P＜0.01).Conclusion The probiotic preparation treatment effectively reduces the TNFαand IL-6 and increases the concentrations of IL-10 and IL-2 in the blood of the patients with severe hepatitis.
Pages: 283-285
Year: 2008 Issue: 4
Journal: CHINESE JOURNAL OF HEPATOLOGY
Keyword: Liver failure; Microbial antagonism; TUmor necrosis factor-alpha; Interleukin;
Abstract: Objective To study the changes of plasma cytokines in patients with severe hepatitis treated with a probiotic preparation.Methods One hundred twelve patients with severe hepatitis treated with a basic regimen were randomly divided into a probiotic preparation treatment group and a control group.Their plasma cytokines such as tumor necrosis factor alpha,interleukin-2,interleukin-6,interleukin-10,were determined by conventional techniques.Results Clinical symptoms of 84.5%of the treatment group were obviously improved.The treatment effectiveness in this group was better than that in the control group (X2=8.888,P＜0.01).It showed that liver functions were significantly improved compared to those of the control group(P＜0.01).After the probiotic preparation therapy,there were significant decreases in the concentrations of TNFα and IL-6.TNFαand IL-6 in the treatment group and in the control group were(109.4±14.7)pg/ml vs(128.7±18.8)pg/ml and(84.3±20.1)pg/ml vs(109.1±18.7)pg/ml respectively(P＜0.01).However,theconcentrations of IL-10andIL-2inthetreatmentgroupincreasedobviously:IL-2 was(59.8±12.2)pg/ml vs(47.1±6.7)pg/ml and IL-10 was(30.6±6.6)pg/ml vs(22.5±6.1)pg/ml (P＜0.01).Conclusion The probiotic preparation treatment effectively reduces the TNFαand IL-6 and increases the concentrations of IL-10 and IL-2 in the blood of the patients with severe hepatitis.
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