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Effects of Pericarpium Arecae on Contraction of Isolated Circular Muscle Strips of Gastric Body in Guinea Pigs
Author(s): 
Pages: 46-47
Year: Issue:  2
Journal: ACTA UNIVERSITATIS TRADITIONIS MEDICALIS SINENSIS PHARMACOLOGIAEQUE SHANGHAI

Keyword:  大腹皮胃体环行肌条4-DAMP加拉明;
Abstract: 目的:观察大腹皮水煎剂对豚鼠胃体环行肌条的收缩活动,并探讨其作用机制.方法:取胃体环行肌条置于灌流肌槽中,累积加入不同浓度的大腹皮水煎剂及分别加入拮抗剂.观察对肌条收缩活动的影响.结果:大腹皮增大胃体环行肌条的收缩波平均振幅、增高肌条张力、加快收缩频率,并呈一定剂量依赖关系;4-DAMP可部分阻断大腹皮对胃体环形肌条收缩波平均振幅的增大作用,而加拉明无明显作用.结论:大腹皮增大胃体环行肌条的收缩波平均振幅,其作用部分通过胆碱能M3受体,而不是M2受体介导.
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