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OBSERVATION OF THE STIMULATING EFFECTS OF GENISTEIN ON BREAST CANCER CELL PROLIFERATION AND IGF-1R mRNA EXPRESSION
Author(s): 
Pages: 1-2,5
Year: Issue:  1
Journal: ACTA ACADEMIAE MEDICAL QINGDAO UNIVERSITATIS

Keyword:  染料木素受体IGF1型受体雌激素乳腺肿瘤;
Abstract: 目的 研究染料木素促人乳癌(MCF-7)细胞增生及IGF-1R mRNA 表达机制.方法 MCF-7细胞常规培养后,用ICI182,780或JB-1与染料木素共同培养,以阻断雌激素受体(ER)或IGF-1R.MTT法观察细胞生长情况,RT-PCR技术观察IGF-1R基因表达情况.结果 染料木素对MCF-7细胞具有增生效应,与对照组相比差异有统计学意义(F=14.627,q=3.76,P<0.05),此效应可以被ER拮抗剂ICI182,780或IGF-1R拮抗剂JB-1完全阻断(q=3.89、4.25,P<0.05);染料木素可增加IGF-1R基因表达(F=21.695,q=4.94,P<0.01),此效应也能够被ICI182,780或JB-1完全阻断(q=5.03、5.89,P<0.01).结论 染料木素可以促进MCF-7细胞的增生和IGF-1R mRNA的表达,此作用可以被ER 拮抗剂ICI182,780或IGF-1R拮抗剂JB-1完全阻断.
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